Issue |
RAIRO-Oper. Res.
Volume 39, Number 4, October-December 2005
|
|
---|---|---|
Page(s) | 227 - 241 | |
DOI | https://doi.org/10.1051/ro:2006007 | |
Published online | 08 April 2006 |
Combinatorial optimization in DNA mapping — a computational thread of the Simplified Partial Digest Problem
1
Institute of Computing Science, Poznan University of
Technology, Piotrowo 3A, 60–965 Poznan, Poland; jblazewicz@cs.put.poznan.pl
2
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland; marta@cs.put.poznan.pl
Received:
22
June
2005
Accepted:
28
October
2005
In the paper, the problem of the genome mapping of DNA molecules, is presented. In particular, the new approach — the Simplified Partial Digest Problem (SPDP), is analyzed. This approach, although easy in laboratory implementation and robust with respect to measurement errors, when formulated in terms of a combinatorial search problem, is proved to be strongly NP-hard for the general error-free case. For a subproblem of the SPDP, a simple O(nlogn)-time algorithm is given, where n is a number of restriction sites.
Key words: Combinatorial optimization / DNA restriction mapping / partial digest / computational complexity.
© EDP Sciences, 2006
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